Intermediate hemoglobins of hemoglobin Kempsey produced by partial oxidation with ferricyanide.
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چکیده
منابع مشابه
The effects of inositol hexaphosphate on the allosteric properties of two beta-99-substituted abnormal hemoglobins, hemoglobin Yakima and hemoglobin Kempsey.
Hemoglobins (Hb) Yakima and Kempsey were purified from patients' blood with diethylaminoethyl cellulose column chromatography. The oxygen equilibrium curves of the two hemoglobins and the effects of organic phosphates on the function were investigated. In 0.1 M phosphate buffer, Hill's constants n for Hb Yakima and Hb Kempsey were 1.0 to 1.1 at the pH range for 6.5 to 8.0 and the oxygen affinit...
متن کاملErythrocytosis secondary to increased oxygen affinity of a mutant hemoglobin, hemoglobin Kempsey.
\TO CLASSES of amino acid substitutions in hemoglobins have profound effects on the major function of this protein, oxygen transport. The first includes the hemoglobins M’ and hemoglobin Kansas,2 which result in cyanoSis in heterozygous subjects and no significant erythrocytosis. The second class, represented by hemoglobin Chesapeake3 and hemoglobin Yakima,4 is assocated with erythrocytosis in ...
متن کاملA review of variant hemoglobins interfering with hemoglobin A1c measurement.
Hemoglobin A1c (HbA1c) is used routinely to monitor long-term glycemic control in people with diabetes mellitus, as HbA1c is related directly to risks for diabetic complications. The accuracy of HbA1c methods can be affected adversely by the presence of hemoglobin (Hb) variants or elevated levels of fetal hemoglobin (HbF). The effect of each variant or elevated HbF must be examined with each sp...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1981
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)43235-8